MicroRNA in neurodegenerative disorders
نویسندگان
چکیده
منابع مشابه
The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders
The microRNA (miRNA) class of non-coding RNAs exhibit a diverse range of regulatory roles in neuronal functions that are conserved from lower vertebrates to primates. Disruption of miRNA expression has compellingly been linked to pathogenesis in neuropsychiatric and neurodegenerative disorders, such as schizophrenia, Alzheimer's disease, and autism. The list of transcript targets governed by a ...
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Type 2 transglutaminase (TG2) is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TG2 is likely to play a modulatory role in nervous system development and has regulator...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2013
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.53.942